To ascertain whether FGF2 exerts an immunomodulatory effect on asthma pathogenesis, 100 ng of rm-FGF2 was administered through intranasal instillation half an hour prior to the HDM challenge three times per week for up to 6 weeks (Fig. 1), and the airway inflammatory cell infiltration levels were compared between the rm-FGF2-treated and control groups through H&E staining and histopathological analysis. This evidence concerns the gene FGF2 and asthma.