IGHE and allergic asthma: Additionally, total IgE and anti-HDM IgE levels in the serum significantly increased in the HDM group (1.00 ± 0.03 vs. 42.97 ± 8.74, P = 0.0063; 0.87 ± 0.04 vs. 4.52 ± 0.73, P = 0.0049, respectively; Fig. 3b), coupled with the elevation of the transcripts of asthma-related cytokines, including IL-4, IL-13, IL-10, and IL-6 (1.01 ± 0.11 vs. 5.58 ± 0.24, P < 0.001; 1.17 ± 0.32 vs. 326.40 ± 39.29, P < 0.001; 1.07 ± 0.23 vs. 13.5 ± 1.12, P < 0.001; 1.02 ± 0.13 vs. 3.15 ± 0.49, P = 0.0117, respectively; Fig. 3c), which represent a typical phenotype for allergic asthma.