To exclude the possibility that the elevated inflammatory cell infiltration scores in the rm-FGF2 combined with HDM group were due to a higher allergic reaction, serum total IgE and anti-HDM IgE levels were measured, and significantly higher serum IgE levels were found in the HDM groups, but no difference between the rm-FGF2 pre-treatment and HDM alone groups was noted (P > 0.05, Fig. 5c). Here, IGHE is linked to allergic disease.