HOTAIR and breast cancer: For example, HOTAIR SNP rs920778 is significantly associated with lung cancer susceptibility which is a protective factor in female patients and non-smokers [79]; HOTAIR rs12826786 SNP increases the incidence of cardiac adenocarcinoma in North China [80]; The rs920778 and rs12826786 polymorphism of HOTAIR increased the incidence of breast cancer in women in southeastern Iran, while rs1899663 had the opposite effect [81].