Moreover, an decrease in anti-inflammatory mediators, i.e., serum total bilirubin, uric acid, C-peptide and glutathione (GSH), and an increase in pro-inflammatory markers, i.e., tumor necrosis factor-α, interleukin (IL)-6, IL-1β, C-reactive protein and neutrophil-to-lymphocyte ratio, have been found to be related to diabetic neuropathy [31–33]. This evidence concerns the gene TNF and diabetic neuropathy.