TERT and astrocytoma (excluding glioblastoma): Patients with the clinicopathological features of age ≥ 45 years, death, astrocytoma, WHO grade III, IDH wild type, 1p19q non-codeletion and MGMTp unmethylated presented significantly higher levels of LPRS, whereas no LPRS differences were observed between patients stratified by gender, KPS and TERT status (Additional file 6: Fig. S6A).