Some of the gene disorders of autophagy signaling are stated as EPG5-associated Vici syndrome, SQSTM1/p62-associated childhood-onset neurodegeneration, SNX14-associated autosomal-recessive spinocerebellar ataxia 20, WDR45-related β-propeller protein-associated neurodegeneration, ATG5-associated autosomal-recessive ataxia syndrome, and numerous types of hereditary spastic paraplegias [144, 159, 160]. The gene discussed is SQSTM1; the disease is hereditary spastic paraplegia.