Zhang and colleagues found that overexpression of transcriptional factor EB (TFEB) attenuated AD progression by decreasing the accumulation of Aβ via regulation of the autophagy-lysosome pathway entailing LAMP-1, cathepsin D, LC3-II, and p62 and alleviating Aβ-induced ROS generation and cell fate [63]. This evidence concerns the gene SQSTM1 and Alzheimer disease.