MCM2 and hepatocellular carcinoma: HCC patients from NODE proteomic cohort were divided into two groups according to an optimal threshold value of -0.047 (unshared log ratio), and Kaplan–Meier survival curve showed that HCC patients with high MCM2 protein levels had worse OS (median OS, 33.9 (29.8–37.9) months vs. 70.7 (64.4–76.9) months; p = 0.00066, log-rank test; Fig. 4C).