To precisely decipher DNA methylation profile of MCM2 promoter region, we analyzed the methylation patterns of CpG islands or CpG island shores in HCC as compared with adjacent nontumor tissue samples from 3 independent HCC datasets with same sequencing platform (Illumina Infinium HumanMethylation450 BeadChip). This evidence concerns the gene MCM2 and hepatocellular carcinoma.