Serum pgRNA strongly correlated to viral replication, expressed by HBV DNA (r = 0.906, p < 0.01) and liver damage, expressed by ALT (r = 0.764, p < 0.01) (Fig. 2b, c) and was predominantly detectable in samples with ALT above the limits proposed by the American Association for the Study of Liver Diseases (AASLD) (35 IU/L for males and 25 IU/L for females) [16]. The gene discussed is GPT; the disease is liver disorder.