STAT3 and breast carcinoma: Currently, there are rare studies on the relationship between ILEI and LIFR, Woosley et al. demonstrated that in breast cancer stem cells, ILEI could bind with the extracellular cytokine binding region of LIFR to promote the tyrosine phosphorylation of LIFR, after this transformation, LIFR enhances the phosphorylation of STAT3, further activating Jak/STAT signaling.