Besides, previous studies revealed that as a transcriptional factor, FOXM1 regulates HCC progression through regulating or interacting with a number of target genes, including but not limited to Aurora Kinase A, Cdc2, Nek2 [42], TPX2 [43], CCNB1 [36], LINC-ROR [42] and UHMK1 [44]. Here, TPX2 is linked to hepatocellular carcinoma.