ICMScore calculates risk score in a tumor as follows: ICMScore = 0.76 × exp(CD40LG) + 0.73 × exp(FLT4) − 0.20 × exp(ADCY2) + 1.97 × exp(CDC25A) + 1.50 × exp(MSH2), where exp(X) denotes the expression level of gene X in the tumor sample. This evidence concerns the gene MSH2 and neoplasm.