MSH2 and sarcoma: Using the TCGA-SARC dataset, we developed a linear risk scoring model (ICMScore) to evaluate the prognostic risk of sarcomas based on the expression levels of five genes, including CD40LG, CDC25A, MSH2, FLT4, and ADCY2. The five genes were involved in five of the 14 pathways for clustering analysis, including T cell receptor signaling (CD40LG), cell cycle (CDC25A), mismatch repair (MSH2), focal adhesion (FLT4), and calcium signaling (ADCY2).