In this study, we dissected the oncogenic role of SPDL1 across all cancer types of TCGA from various aspects, including gene expression, genetic alteration, methylation level, protein phosphorylation, immunology, survival prognosis, and gene enrichment analysis, which can further uncover the potential molecular mechanism of SPDL1 in cancers and its value in clinical prognosis of cancer patients. The gene discussed is SPDL1; the disease is cancer.