For lung cancer in TCGA, the relationship between survival prognosis and SPDL1 expression was detected, and we found that high SPDL1 expression was related with poor OS and DFS in LUAD (P = .0015, P = .03, respectively) but not in LUSC (P>.05) (Fig. 2) based on the GEPIA2 tool. This evidence concerns the gene SPDL1 and lung cancer.