GPX4 and acute kidney injury: Furthermore, VDR (a karyophilic protein, that binds 1,25(OH)2D3 to achieve its biological functions (Li et al. 1997)) was also shown to be associated with ferroptosis, and VDR activation was proposed to reverse ferroptosis-related changes in cisplatin-induced AKI through the trans-regulation of GPX4 (Hu et al. 2020).