Chronic opioid therapy in the previous 3 months before surgery, conversion to open surgical technique, BMI > 30 kg/m2or < 18 kg/m2, postoperative recovery in intensive care unit, chronic therapy with antidepressants, known diagnosis of epilepsy or therapy with antiepileptic drugs, bilirubin level > 3.0 mg/dL, aspartate aminotransferase and/or alanine aminotransferase > 250 IU, creatinine level >1.4 mg/dL, pregnancy or lactation, known allergy to any drug used in the study, local infection at the block site, and drug or alcohol addiction. This evidence concerns the gene GPT and Addictive alcohol use.