SEMA3F and Aganglionic megacolon: Wang et al. [18] review the current diagnostic criteria of chronic idiopathic megacolon, introducing the possibility to diagnose this condition when the radiological imaging is not conclusive through the intraluminal measurements of colonic compliance by measuring volume at 20, 32 and 44 mmHg distension; they investigate also different genetic associations with chronic acquired megacolon beyond childhood: in particular, the association of SEMA3F gene in a family with megacolon seemed to play a central role in the etiopathogenesis of this pathology.