Accordingly, there was a significant inverse correlation between CD4+ T-cell counts and IL-1RA (P = 0.002), CXCL9 (P < 0.0001), and CXCL10 (P = 0.0014) (Figure 1, D–F), supportive of dysregulated immune activation in TB/HIV–co-infected patients. This evidence concerns the gene CD4 and tuberculosis.