Concerning clinical data, NXP2+ cases more frequently showed manifestations typical of DM as facial (p = 0.0013; OR 2.18, 95% CI 1.2–3.9) and heliotrope rash (p < 0.0001; OR 3.4, 95% CI 1.88–6.2), periorbital oedema (p = 0.055; OR 2.38, 95% CI 1–5.37) and calcinosis (p = 0.017; OR 3, 95% CI 1.25–7.27). Here, MORC3 is linked to dermatomyositis.