TNF and myeloid sarcoma: Moreover, the cytokine profile of depressed MS patients is characterized by increased levels of proinflammatory cytokines, including TNF-α, IL-1β, and IL-6 in both cerebrospinal fluid and peripheral blood; furthermore, increased levels of IL-6 and decreased levels of IL-4 have been reported in depressed MS patients when compared to non-depressed MS patients and healthy controls and CD8 + T lymphocyte levels are significantly increased in MS depressed versus non-depressed patients [25].