Based on Han S. and colleagues experience, PD/PD-L1 significance in meningiomas is consistent as showed by CD68+ double staining of tumor-infiltrating cells in a significant subset of meningiomas cases proposing PD-L1 via could play a biologic role in the hostility for grade II/III and radiotherapy failed meningiomas [3]. The gene discussed is CD274; the disease is neoplasm.