These analyses together with transcriptomic profiling of BMDMs from WT and PYK2 KO mice (Figure 6D), secretome profiling of PYK2‐depleted TNBC cells (Figure 3C; Figure S3A, Supporting Information), and mechanistic studies (Figures 3, 4, 6, and 7), suggest that PYK2 ablation impairs macrophage recruitment and polarization through cell‐autonomous mechanisms and by tumor–macrophage CCL2/CCR2/CXCR4 and IL‐4/IL‐4R crosstalk signaling. This evidence concerns the gene CXCR4 and neoplasm.