PTK2B and breast cancer: In a second model, where WT BC cells (EO771) were implanted into PYK2 KO mice (Figure 2F), we also observed a significant reduction in tumor volume (≈50% at the endpoint, p = 0.0004) compared to WT BC cells grown in WT background (Figure 2G), thus highlighting the impact of PYK2 ablation only within the TME.