The profound effects of PYK2 ablation on TAM numbers (Figures 1, 2, and 5F; Figure S5F, Supporting Information) together with the known effects of TAMs on tumor angiogenesis[54] led us to assess the influence of PYK2 ablation either in the BC cells and/or in the TME on angiogenesis using the described different mouse models. The gene discussed is PTK2B; the disease is breast cancer.