Our finding that PYK2 regulates levels of key cell surface receptors including IL‐4R, CXCR2, CXCR4, and Notch1 (Figures 4, 6, and 7) and consequently, modulates critical signaling pathways in BC–TAM communication, highlights its therapeutic potential and the clinical implications of our studies. This evidence concerns the gene CXCR4 and breast cancer.