CXCR4 and breast carcinoma: Indeed, CXCR4 blockade significantly reduced chemotaxis of pro‐tumorigenic macrophages in oral squamous cell carcinoma[67] and several CXCR4 antagonists, as well as of CCR2 and CSF1R, are currently in clinical trials.[68] Nevertheless, targeting of PYK2 alone might not be sufficient for cancer therapy, whereas combining PYK2 targeting with other therapeutic agents could be beneficial for subsets of breast cancer patients.