The clinicopathological analysis demonstrated that high expression of DNMT1 protein was closely correlated with younger age (p = 0.017), high AFP level (p = 0.011), tumor venous invasion (p < 0.001), and a high BCLC (the Barcelona Clinic Liver Cancer staging) stage (p = 0.001) with the χ2 test (Table S2). This evidence concerns the gene DNMT1 and neoplasm.