However, mRNA expression of DNMT3A, DNMT3B, and DNMT3L was not correlated with ZNF191 expression in 967 cancer cell lines and HCC tissues (373 samples) of TCGA database compared with that of DNMT1 with ZNF191 expression (Tables S6 and S7), and ZNF191 protein is not enriched in the promoter of the three genes (Tables S6 and S7 of our previous study24). Here, DNMT3L is linked to cancer.