Taken together, our findings suggest the pro‐proliferation effect of ZNF191/DNMT1/p‐AKT axis in hepatoma cells, which implies ZNF191 status in HCC tissues may affect the therapeutic effect of PI3K inhibitors3 and DNMTs inhibitors,31 and warrants further study to guarantee precise treatment of the disease. This evidence concerns the gene DNMT1 and hepatocellular carcinoma.