We revealed that TRAM is at least partially involved in the generation of both low-grade inflammatory monocytes, as well as the development of exhaustion, through facilitating Signal Transducer and Activator of Transcription 1 (STAT1) / IRF7 activation and induction of selective exhaustion markers such as S100 Calcium Binding Protein A8 (S100A8), often seen in patients with COVID-19. This evidence concerns the gene IRF7 and COVID-19.