Thus, rather than being used as a monotherapy, the efficacy of VEN is currently being tested in clinical trials in combination with conventional chemotherapy for the treatment of relapsed/refractory (R/R) BCP-ALL, including patients with MLLr BCP-ALL (ClinicalTrials.gov: NCT03808610, and NCT03504644). Here, OPN1SW is linked to acute lymphoblastic leukemia.