We observed an increase in NOXA-encoding mRNA in response to AUR (Fig. 6A) and concentration-dependent accumulation of NOXA protein in MLLr BCP-ALL cell lines (Fig. 6B), PDXs (n = 8, Fig. 6C), as well as in other BCP-ALL cell lines (Supplementary Fig. 10A, B). The gene discussed is OPN1SW; the disease is acute lymphoblastic leukemia.