To further explore the role of BOK, we used the mutant Kras-driven mouse lung adenocarcinoma cell line LKR10 [22] to generate Bok-deficient cells by CRISPR/Cas9 (LKR10 Bok−/− and, as control, LKR10 LacZ, Fig. S2a). The gene discussed is BOK; the disease is lung adenocarcinoma.