Several other studies have also suggested that a high expression of CTLA-4+ on T-cells is linked to a favorable disease outcome or tumor features in 289 squamous cell lung cancer46, 162 testicular germ cell tumors47, 130 breast cancers32, 45 mesothelioma patients48, and 39 B-cell chronic lymphocytic leukemia49. Here, CTLA4 is linked to mesothelioma.