People with C9orf72 gene expansion, VCP gene inversion, and ERBB4 gene insertion had worse survival (p = 6.7 × 10−5) than people with ALS with no overlapping structural variation in C9orf72, VCP, and ERBB4 genes (Supplementary Fig. 7). This evidence concerns the gene ERBB4 and amyotrophic lateral sclerosis.