ERBB4 and amyotrophic lateral sclerosis: People with ALS and VCP inversion, ERBB4 insertion and C9orf72 gene expansion died on average 4.8 years younger than those with no reported structural variations in those genes (p = 5.0 × 10−4, 95% CI for the difference 1.9 to 6.7 years) (Table 4).