Kaplan–Meier survival analysis showed that people with ALS with respiratory onset had worse survival than those with spinal onset ALS, and better survival than those with bulbar onset ALS (log rank p = 6.6 × 10−34) (Supplementary Fig. 5) but in the subset with ERBB4 insertion there was no difference in survival (log rank p = 0.15) (Supplementary Fig. 6). The gene discussed is ERBB4; the disease is Onset.