MAT1A and acute myeloid leukemia: Using Phos-TagTM gels, which capture phosphorylated Ser/Thr/Tyr and His/Asp/Lys, and cytosolic and mitochondrial fractions of ethanol-treated AML-12 cells, we found that ethanol promotes MATα1 phosphorylation in the cytosol (Fig. 4b).