MAT1A and acute myeloid leukemia: Whilst PIN1 knockdown increased by 300 and 150% the mitochondrial content of MATα1 in AML-12 and HepG2 cells, respectively (Fig. 3c, e), PIN1 overexpression reduced MATα1 mitochondrial content by 60% in AML-12 and 40% in HepG2 cells (Fig. 3d, f).