Interestingly, the patients with highly elevated TRB repertoire richness post-AZA showed these low pGen clusters at a significantly higher frequency after the first course of AZA compared to the AML patients without immunological response (1.7 vs 0.4 low pGen clusters per sample; P = 0.001, Fig. 6B). This evidence concerns the gene THRB and acute myeloid leukemia.