Moreover, both TAM-secreted exosomes and hsa_Circ_0020256 induced increases in the numbers of Ki67 and E2F3 positive cells in xeno-engrafted CCA tumor tissues, while hsa_Circ_0020256 siRNA reversed those increases (Fig. 8E and Supporting Fig. 5E). The gene discussed is E2F3; the disease is cholangiocarcinoma.