The latter observation is in line with the previously reported key contribution of IFN-γ in preventing B16 tumor growth in vivo.40 To further test whether IFN-γ is important for the anticancer effects of cGAMP mediated by CD4 T cells, we have repeated our adoptive transfer model experiments presented in figure 1A upon neutralization of IFN-γ. The gene discussed is IFNG; the disease is neoplasm.