Since these findings are in line with the enrichment of HSP-genes and IEGs in total tissue NAWM compared to CWM (Fig. S1b), this strongly suggests that HSP gene and IEG expression of macrophages in NAWM compared to NACT is not an intrinsic property of WM macrophages, but rather is MS pathology associated. Here, HSP90B2P is linked to myeloid sarcoma.