Patients carrying the C215Y GNAO1 mutation do not reveal signs of epilepsy [8, 9] (Table 1), unlike patients with several other point mutations in GNAO1. In agreement with these clinical findings, we did not observe any signs of behavioral seizures (such as facial automatisms, myoclonus, jumping and running or tail or hindlimb extension) in C215Y/ + or C215Y/C215Y mice during the animal handling and behavioral assessment procedures. This evidence concerns the gene GNAO1 and epilepsy.