The modeling of GNAO1 encephalopathy has also been performed in C.elegans, with the nematodes heterozygous for S47G or A221D mutations revealing the dominant "unlaid eggs" phenotype indicative of effects in motor neurons, while the heterozygous G42R or R209C mutations produced the dominant aldicarb hypersensitivity effects [36, 37]. The gene discussed is GNAO1; the disease is Encephalopathy.