We evaluated right ventricular hypertrophy (Fig. 4E), right ventricular systolic pressure (RVSP) (Fig. 4F), echocardiography and hemodynamics (Fig. 4G) and found that AIF overexpression inhibited the pulmonary hypertension index induced by hypoxia in vivo. This evidence concerns the gene AIFM1 and pulmonary arterial hypertension.