For instance, the circRNA_010383 has been reportedly shown to promote proteinuria and cause the exacerbation of renal fibrosis in DN by sponging the miRNA-135a [10], while the lncRNA NR_038323 acts as a tumor suppressor in DN and suppresses renal fibrosis by endogenously targeting the miR-324-3p/DUSP1 axis [20]. Here, DUSP1 is linked to liver dysplastic nodule.