In Ghana, three main Plasmodium species cause malaria, namely P. falciparum, P. malariae and P. ovale [3, 22], and the main diagnostic tools used to identify malaria among symptomatic malaria patients are microscopy and HRP2 (histidine-rich protein 2)-based malaria RDT (rapid diagnostic test) kits. This evidence concerns the gene HDGFL2 and malaria.