However, variations in insulin release, pancreatic cell functions, hemoglobin A1C level, and/or response to pancreatic KATP channel agonists [21, 24, 25] as well as T2DM, GDM, ulcerative colitis, Crohn’s disease, obesity, and/or birth weight [19, 26–28] have been reported to be associated with some intron variants; rs7754840, rs7756992, and rs10946398 of this gene. Here, INS is linked to type 2 diabetes mellitus.