Moreover, changes in the expression levels of pyruvate dehydrogenase kinase 1(PDK1), glucose transporter 1(GLUT1), LDHA, and pyruvate kinase M2 (PKM2) regulate macrophage glycolysis, the release of proinflammatory cytokines, and macrophage activation during sepsis [58]. This evidence concerns the gene SLC2A1 and Sepsis.