Aberrant expression of Bcl-2-associated athanogene 3 (BAG3) can reprogram glucose metabolism in pancreatic ductal adenocarcinoma, thus increasing expression of Hexokinase II (HK-II) which is the first key enzyme of glycolysis by inducing IMP3 recruitment [26]. The gene discussed is BAG3; the disease is pancreatic ductal adenocarcinoma.