In addition, compared with those who have low levels of Exo-PD-L1, the OS of pancreatic cancer and GC patients with high Exo-PD-L1 levels was markedly lower; thus, PD-L1 expression on exosomes can be considered to be a negative prognostic factor for these cancers [125, 126]. This evidence concerns the gene CD274 and pancreatic neoplasm.