As an example, serine and arginine rich splicing factor 10 (SRSF10), belonging to the SR protein family, binds to the 5′-end and 3′-end of circ-ATXN1 pre-mRNA and increases the circ-ATXN1 biogenesis and inhibits the SRSF10, resulting in a dramatically repression of the tube formation in glioma endothelial cells (GECs). Here, ATXN1 is linked to glioma.