Additionally, He et al. declared that the overexpressed circ-SHKBP1 could up-regulate the forkhead box P1/P2 (FOXP1/FOXP2) by sponging the miR-544a/miR-379 and the further activation of PI3K/Akt pathway in U8 glioma-exposed endothelial cells (GECs). Here, AKT1 is linked to central nervous system cancer.