AKT1 and glioma: Furthermore, circ-EPB41L5, which is down-regulated in GBM, is a circRNA gene that can inactivate the miR-19a, thereby inhibits the phosphorylation of the Akt through the EPB41L5 overexpression, and subsequently can repress the invasion and metastasis of glioma cells to inhibit the GBM tumorigenesis.