Interestingly, Liu Y. and colleagues reported that silencing circPVT1 in osteosarcoma cell lines decreased the expression of N-cadherin (Neural cadherin), Vimentin and Snail while it increased the expression of E-cadherin (Epithelial cadherin) suggesting circPVT1’s role in epithelial-mesenchymal transition (EMT). This evidence concerns the gene CDH2 and osteosarcoma.