Exposed to hypoxia, FOXO3 is such one that downregulated METTL3 raised resistance to sorafenib in HCC by decreasing its mRNA stabilization in a YTHDF1-reliant fashion in that the concomitant m6A decrease enhanced the level of autophagosomes and LC3 accumulation [120]. The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.