GSDMD and infection: Pyroptosis, a lytic form of cell death whose definitive hallmark genes are NLR pyrin domain containing 3 (NLRP3), apoptotic speck-like protein containing CARD (ASC), cleaved Caspase-1, Gasdermin-D (GsdmD) p30, IL-1β and IL-18, plays a prominent role in response to infection, ultimately fueling inflammation.