Nowadays, researchers mainly focus on the biological function of miR-199a; and the roles of miR-199b are largely unknown. Mussnich et al. [14] identified both miR-199a-5p and miR-199b-3p as significant differentially expressed miRNAs between CTx-sensitive and CTx-resistant CRC cells. Here, CYP27A1 is linked to colorectal carcinoma.