MACC1 and colorectal carcinoma: Moreover, IHC analysis showed that the expression level of MACC1 (a novel biomarker for the prediction of metastasis for CRC) in the CTx + antagomiR-199b-3p group was higher than that in other groups, suggesting that miR-199b-3p might be involved in the metastasis of CRC (Fig. 6E).