CYP27A1 and colorectal carcinoma: The results showed that antagomiR-199b-3p had little influence on tumorgenesis alone; however, combined with CTx, SW480-CTxR cells stably suppressing miR-199b-3p remarkably inhibited tumorigenesis, indicating antagomiR-199b-3p could enhance the efficacy of CTx to CRC in the chemoresistant context (Fig. 6A–D).