Our study exhibited that overexpressing CRIM1 effectively enhanced the anti-tumor effects of CTx on the cell proliferation, apoptosis, migration, and invasion of CRC-CTxR cells, hinting that CRIM1 OE could reverse acquired resistance of CRC-CTxR cells to CTx (Fig. 4A–D, Additional file 2: Fig. S2B). The gene discussed is CRIM1; the disease is colorectal carcinoma.