Cetuximab (CTx), an epidermal growth factor receptor (EGFR) inhibitor, is approved by FDA for the first-line therapy for EGFR-expressing metastatic CRC with wild-type RAS, which competitively blocks the EGFR extracellular domain to inhibit the phosphorylation of EGFR thus suppressing the proliferation and metastasis of CRC cells [4, 5]. The gene discussed is EGFR; the disease is colorectal carcinoma.