To study the mechanisms of glucose ingestion by PC tumour cells and explore novel effective targets for PC diagnosis and treatment, we examined the expression profile and survival relevance of SGLTs in PC and elucidated the specific prognostic significance of SGLT-1, in contrast to GLUT-1, which has been reported to be correlated with a poor prognosis. The gene discussed is SLC5A1; the disease is pachyonychia congenita.