Compared with the samples of normal lung tissues, LUAD tissues, non-small cell lung cancer and brain metastasis of lung cancer, we found that the expression of ZC3H12D in different immune cell types, including conventional CD4 T cells, regulatory T cells, monocytes or macrophages, would change under different conditions, which reflected the plasticity of ZC3H12D to a certain extent. Here, CD4 is linked to lung cancer.