In some reports or guidelines on the noninvasive diagnosis of liver fibrosis by FibroScan, it has been suggested that the LSM cutoff value should be adapted to the ALT level since ALT levels tend to influence the LSM in CHB [39] and because ALT increases the LSM value in FibroScan and is an important factor or confounding factor affecting the accuracy of LSM, thus reducing its diagnostic efficiency [22, 40]. The gene discussed is GPT; the disease is Hepatic fibrosis.