PTX3 and central nervous system cancer: During tumourigenesis, elevated PTX3 levels have been detected in various cancers, including liposarcoma, glioma, ovarian cancer, lung cancer, pancreatic carcinoma, prostate carcinoma and hepatocellular carcinoma, and are correlated with the grade of malignancy and a poor prognosis.32, 33, 34, 44, 45, 46, 47