As the expression of PRMT3 was relatively higher in SNU398 cells and its expression in Huh7 cells relatively low, we selected these two HCC cell lines to establish stable cell lines SNU398‐Lv‐shPRMT3‐1, SNU398‐Lv‐shPRMT3‐2 and Huh7‐Lv‐PRMT3 using lentivirus infection (Figure 2A). This evidence concerns the gene PRMT3 and lentivirus infection.