The results showed that the mRNA expression of PRMT1 (fold change = 1.54, p = .002), PRMT2 (fold change = 1.22, p = .0193), PRMT3 (fold change = 1.90, p < .001), PRMT4 (fold change = 1.40, p < .001), PRMT5 (fold change = 1.34, p < .001) and PRMT7 (fold change = 1.21, p = .0043) was higher in HCC tissues than in normal liver tissues. This evidence concerns the gene PRMT5 and hepatocellular carcinoma.