NPPB and hydrops fetalis: With respect to the secondary outcome measures, the cumulative 180-day incidence of all-cause death was significantly higher in the BNP worsening group than in the no-marked BNP change group and the marked BNP improvement group (9.6%, 4.8%, and 4.1%, respectively, log-rank P = 0.04) (Fig 4B) and the cumulative 180-day incidence of hospitalization for HF was also significantly higher in BNP worsening group and the no-marked BNP change group than in the marked BNP improvement group (21.2%, 9.9%, and 2.8%, respectively, log-rank P<0.0001) (Fig 4C).