At 6-month visit, the BNP worsening group had a higher LVMI and tricuspid regurgitation pressure gradient (TRPG), a greater LAD and diameter of inferior vena cava (IVC), and a higher prevalence of moderate/severe mitral regurgitation (MR) and tricuspid regurgitation (TR) than the marked BNP improvement and no-marked BNP change groups. The gene discussed is NPPB; the disease is Mitral regurgitation.