These results indicate that IL-6 secretion from fibroblasts is normally lower than that detected in HNSCC cells, whereas irradiation increases IL-6 secretion from fibroblasts; it is also suggested that IL-6 plays a role in the migration of HNSCC cells triggered by fibroblast irradiation (see Fig 2). The gene discussed is IL6; the disease is head and neck squamous cell carcinoma.