AGT and ischemia: The renin-angiotensin system is a biochemical pathway with a long-term and integral role in the pathogenesis of dementia, largely driven by angiotensin II.6 Animal and mechanistic data show that antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors promote beneficial effects on the brain, possibly through reduced ischemia, enhanced cerebral blood flow, and improved spatial memory processing, among other pathways.7,8,9,10,11,12,13,14,15,16