Although use of antihypertensive medications that stimulate (angiotensin II receptor type 1 blockers, dihydropyridine calcium channel blockers, and thiazide diuretics) vs inhibit (angiotensin-converting enzyme [ACE] inhibitors, β-blockers, and nondihydropyridine calcium channel blockers) type 2 and 4 angiotensin II receptors has been associated with lower risk of dementia, their association with cognitive outcomes in hypertension trials, with BP levels in the range of current guidelines, has not been evaluated. This evidence concerns the gene ACE and Hypertension.